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Cover shows a confocal light micrograph of orexin receptors (red) in the brain. Also seen are neurons (green). The forthcoming review article by Fiuza & Arias (scheduled for the September 2007 issue (Vol.194-3)) describes the multiple roles of Notch and how various factors regulate. Notch signalling. To read the accepted preprint of this paper go to: http://journals.endocrinology.org/joe/fca/JOE70242.htm Credit: C J Guerin, PhD, MRC Toxicology Unit/Science Photo Library

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