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Cover shows a coloured transmission electron micrograph of a slice through a cell of the hormone-secreting islet of Langerhans in the mammalian pancreas. The dark red round shapes in pink spaces are membrane-bound secretory granules. Glauser and Schlegel�s forthcoming review article (scheduled for May 2007 (Vol 193-2)) focusses on the emerging role of FOXO transcription factors in pancreatic β cells. To read the accepted preprint of this paper go to: http://journals.endocrinology.org/joe/FCA/FCACont.htm

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