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This Article Accepted manuscript (PDF) All Versions of this Article: JOE-08-0526v1 201/1/1    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hoffman, B. Articles by Jones, S. Search for Related Content PubMed PubMed Citation Articles by Hoffman, B. Articles by Jones, S.

B Hoffman, Cancer Endocrinology, BC Cancer Research Center, Vancouver, British Columbia, Canada
S Jones, Micheal Smith Genome Sciences Centre, Vancouver, V5Z 4S6, Canada

Correspondence: Steven Jones, Email: sjones{at}bcgsc.ca

Abstract

The transcriptional networks underlying mammalian cell development and function are largely unknown. The recently described use of flow cell sequencing devices in combination with chromatin immunoprecipitation (ChIP-seq) stands to revolutionize the identification of DNA-protein interactions. As such, ChIP-seq is rapidly becoming the method of choice for the genome wide localization of histone modifications and transcription factor binding sites. As further studies are performed, the information generated by ChIP-seq is expected to allow the development of a framework for networks describing the transcriptional regulation of cellular development and function. However, to date this technology has been only applied to a small number of cell types, and even fewer tissues, suggesting a huge potential for novel discovery in this field.

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