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This Article Accepted manuscript (PDF) All Versions of this Article: JOE-08-0294v1 199/2/151    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kassi, E. Articles by Papavassiliou, A. Search for Related Content PubMed PubMed Citation Articles by Kassi, E. Articles by Papavassiliou, A.

E Kassi, Biological Chemistry, University of Athens, Athens, Greece
A Papavassiliou, BIOLOGICAL CHEMISTRY, UNIVERSITY OF ATHENS MEDICAL SCHOOL, ATHENS, 11527, Greece

Correspondence: Athanasios Papavassiliou, Email: papavas{at}med.uoa.gr

Abstract

Recent studies have indicated a novel function for skeleton unraveling its importance in the control of energy metabolism. In the present commentary, we speculate on the meaning for bone to act as a "rheostat" modulating glucose metabolism, and how the primitive way of communication between bone and energy metabolism through switch on/off genes (like Esp) evolved to a more complicated "talking" via gain/loss of hormones activity (like osteocalcin) by carbo-/decarboxylation process.