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This Article Accepted manuscript (PDF) All Versions of this Article: JOE-08-0174v1 198/2/347    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fortunato, R. Articles by Pires de Carvalho, D. Search for Related Content PubMed PubMed Citation Articles by Fortunato, R. Articles by Pires de Carvalho, D., MD, PhD

R Fortunato, Laboratorio de Fisiologia Endocrina Doris Rosenthal, Instituto de Biofisica Carlos Chagas Filho, Rio de Janeiro, Brazil
D Ignacio, Laboratorio de Fisiologia Endocrina Doris Rosenthal, Instituto de Biofisica Carlos Chagas Filho, Rio de Janeiro, Brazil
A Padron, Laboratorio de Fisiologia Endocrina Doris Rosenthal, Instituto de Biofisica Carlos Chagas Filho, Rio de Janeiro, Brazil
R Ribeiro, Laboratorio de Cardiologia Celular e Molecular, Instituto de Biofisica Carlos Chagas Filho, Rio de Janeiro, Brazil
M Marassi, Laboratorio de Fisiologia Endocrina Doris Rosenthal, Instituto de Biofisica Carlos Chagas Filho, Rio de Janeiro, Brazil
D Rosenthal, Laboratorio de Fisiologia Endocrina Doris Rosenthal, Instituto de Biofisica Carlos Chagas Filho, Rio de Janeiro, Brazil
J Werneck-de-Castro, Laboratorio de Biologia Muscular e do Exercicio, Departamento de Biociencias da Atividade Fisica, Rio de Janeiro, Brazil
D Pires de Carvalho, Instituto de Biofisica Carlos Chagas Filho, UFRJ, Rio de Janeiro, Brazil

Correspondence: Denise Pires de Carvalho, Email: dencarv{at}biof.ufrj.br

Abstract

The hypothalamic-pituitary-thyroid axis is affected by acute exercise, but the mechanisms underlying thyroid function changes after exercise remain to be defined. The aim of this study was to elucidate the effects of a session of acute exercise in treadmill at 75% of maximum oxygen consumption on thyroid function of rats. Male Wistar rats were divided into 5 groups: control (without exercise), sacrificed immediately after (0 min) and 30, 60 and 120 minutes after the end of exercise session. A significant increase in serum T3 occurred immediately after exercise, with a gradual decrease thereafter, so that 120 min after the end of exercise serum T3 was significantly lower than in controls. Total T4 increased progressively reaching values significantly higher than in the control group at 120 min. T3 to T4 ratio was significantly decreased 60 and 120 min after exercise, indicating impaired T4 to T3 conversion. Liver type 1 deiodinase activity (D1) significantly decreased at 60 and 120 min, while pituitary D1 increased progressively from 30 min to 120 min after the exercise, and thyroid D1 was increased only immediately after the end of exercise. Brown adipose tissue (BAT) type 2 deiodinase activity (D2) was significantly lower at 30 min, but pituitary D2 remained unchanged. No changes in serum thyrotropin were detected, while serum corticosterone was significantly higher at 30 min after exercise. Our results demonstrate that decreased liver D1 and BAT D2 might be involved in the decreased T4 to T3 conversion detected after an exercise session in treadmill.

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