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Accepted Preprint first posted online on 4 June 2008

Journal of Endocrinology 2008;198:439.

Journal of Endocrinology (2008) In press
DOI: 10.1677/JOE-08-0161
© 2008 Society for Endocrinology
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REVIEW

Hedgehog signalling in endocrine development and disease

Peter King, Leonardo Guasti and Ed Laufer

P King, Endocrinology, Queen Mary, University of London, London, EC1M 6BQ, United Kingdom
L Guasti, Endocrinology, Barts and the London School of Medicine, London, United Kingdom
E Laufer, Pathology and Cell Biology, Columbia University, New York, United States

Correspondence: Peter King, Email: p.j.king{at}qmul.ac.uk

Abstract

The hedgehog pathway is an evolutionarily conserved signalling pathway that is required for many essential tissue and cellular properties such as patterning fields of cells or regulating cell differentiation and proliferation. Disruption of the pathway results in serious pathologies. In this review we provide an update on recent findings in the field of vertebrate hedgehog signalling and also describe contributions of hedgehog signalling to the development, maintenance and pathology of endocrine tissues.




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