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P King, Endocrinology, Queen Mary, University of London, London, EC1M 6BQ, United Kingdom
L Guasti, Endocrinology, Barts and the London School of Medicine, London, United Kingdom
E Laufer, Pathology and Cell Biology, Columbia University, New York, United States
Correspondence: Peter King, Email: p.j.king{at}qmul.ac.uk
Abstract
The hedgehog pathway is an evolutionarily conserved signalling pathway that is required for many essential tissue and cellular properties such as patterning fields of cells or regulating cell differentiation and proliferation. Disruption of the pathway results in serious pathologies. In this review we provide an update on recent findings in the field of vertebrate hedgehog signalling and also describe contributions of hedgehog signalling to the development, maintenance and pathology of endocrine tissues.
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