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This Article Accepted manuscript (PDF) All Versions of this Article: JOE-09-0359v1 JOE-09-0359v2    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Sugden, M. C Articles by Holness, M. J PubMed PubMed Citation Articles by Sugden, M. C Articles by Holness, M. J

M Sugden, Centre for Diabetes, Queen Mary University of London, London, E1 2AT, United Kingdom
P Caton, Centre for Diabetes, Queen Mary University of London, London, United Kingdom
M Holness, Centre for Diabetes, Queen Mary University of London, London, United Kingdom

Mary C Sugden, Email: m.c.sugden{at}qmul.ac.uk

This contribution describes recent advances in our knowledge of the regulatory interactions influencing the expression of PPAR-regulated genes. We address recent advances highlighting the role of the PGC-1s and lipin 1in co-ordinating the expression of genes controlling nutrient handling. We evaluate the possibility that SIRT1 lies at the heart of a regulatory loop involving PPARalpha, PGC-1alpha and lipin 1 that ultimately controls the metabolic response to varying nutrient and physiological signals via a common mechanism mediated by post-translation modifications (deacetylation) of both PPARalpha and PGC-1s. Finally, we comment on the potential of pharmaceutical manipulation of these targets as well as the possible problems associated with this strategy.