HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Accepted manuscript (PDF) All Versions of this Article: JOE-09-0116v1 203/3/327    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Sen Gupta, P. Articles by Chapple, J Search for Related Content PubMed PubMed Citation Articles by Sen Gupta, P. Articles by Chapple, J

P Sen Gupta, Centre for Endocrinology, Barts and the London School of Medicine and Dentistry, London, United Kingdom
N Prodromou, Centre for Endocrinology, Barts and the London School of Medicine and Dentistry, London, United Kingdom
J Chapple, Centre for Endocrinology, Barts and the London School of Medicine and Dentistry, London, EC1M 6BQ, United Kingdom

Correspondence: J Chapple, Email: j.p.chapple{at}qmul.ac.uk

Primary cilia are sensory organelles that protrude from the surface of most mammalian cell types. In humans and mice, mutations in proteins required for normal cilia function have been identified as causing a class of disorders with overlapping phenotypes known as ciliopathies. Recent evidence has linked obesity in ciliopathies to both the regulation of energy homeostasis in the hypothalamus and to adipogenesis. This article considers the role of cilia in these processes and whether cilia dysfunction may be relevant to more common forms of obesity.