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This Article Accepted manuscript (PDF) All Versions of this Article: JOE-07-0599v1 198/1/111    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Kim, K.-A. Articles by Park, B.-H. PubMed PubMed Citation Articles by Kim, K.-A. Articles by Park, B.-H.

K Kim, Biochemistry,, Medical School and Institute for Medical Sciences, Chonbuk National University, Jeonju, Korea, Republic of
S Ka, Biochemistry,, Medical School and Institute for Medical Sciences, Chonbuk National University, Jeonju, Korea, Republic of
W Moon, Pathology, Medical School and Institute for Medical Sciences, Chonbuk National University, Jeonju, Korea, Republic of
H Yi, Biochemistry, Dental School and Institute of Oral Biosciences, Chonbuk National University, Jeonju, Korea, Republic of
Y Lee, Oral Anatomy, Dental School and Institute of Oral Biosciences, Chonbuk National University, Jeonju, Korea, Republic of
K Kwon, Physiology, of Oriental Medicine, Wonkwang University, Iksan, Korea, Republic of
J Park, Biochemistry,, Medical School and Institute for Medical Sciences, Chonbuk National University, Jeonju, Korea, Republic of
B Park, Biochemistry, Medical School and Institute for Medical Sciences, Chonbuk National University, Jeonju, 561-756, Korea, Republic of

Correspondence: Byung-Hyun Park, Email: bhpark{at}chonbuk.ac.kr

Abstract

Dermcidin (DCD), an antimicrobial peptide that is secreted by sweat glands, is reportedly a human homologue of mouse proteolysis-inducing factor. This study was conducted to investigate the effect of DCD on body fat mobilization. The expression level of DCD in the livers of Ad-DCD-injected mice was higher than in those of Ad-β-gal-injected mice 7 days after injection. In addition, injection with the Ad-DCD virus led to decreased body weight and epididymal fat mass when compared with controls. The plasma triglyceride level was decreased, whereas the free fatty acid and glycerol levels were increased in the Ad-DCD-injected group. Epididymal adipose tissues obtained from Ad-DCD-injected mice consisted of smaller adipocytes than tissues obtained from Ad-β-gal-injected mice. The gene expression profiles revealed up-regulation of hormone-sensitive lipase and adipose fatty acid binding protein, both of which are involved in adipocyte lipolysis, in Ad-DCD-injected mice and this lipolytic effect of DCD paralleled the increase of circulating TNF- level that was observed. The perilipin levels in adipose tissue were decreased in Ad-DCD-injected mice when compared with those of the control mice. Taken together, these results suggest that DCD-mediated body fat reduction might occur as a result of TNF--induced down-regulation of perilipin in adipose tissue.