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The binding of ¹²⁵I-labelled insulin and ¹²⁵I-labelled insulin-like growth factor (IGF) to cultured arterial smooth muscle cells from rats was studied during various growth states of the cells. The level of binding of ¹²⁵I-labelled insulin to the cells was low in growing cells and high in stationary cells. The level of ¹²⁵I-labelled IGF binding to the cells was high in growing cells and low in stationary cells. In addition, the effect of unlabelled IGF and insulin on the binding of both ¹²⁵I-labelled hormones to the cells was examined during various growth states. In growing cells insulin displaced ¹²⁵I-labelled insulin from its binding sites; IGF competed weakly with ¹²⁵I-labelled insulin for the binding sites. In parallel, IGF displaced ¹²⁵I-labelled IGF binding whereas insulin competed weakly with ¹²⁵I-labelled IGF for the binding sites. In stationary cells both hormones displaced ¹²⁵I-labelled IGF binding. Insulin-like growth factor also displaced ¹²⁵I-labelled insulin binding whereas insulin could not significantly displace ¹²⁵I-labelled insulin from the binding sites. Insulin only competed with ¹²⁵I-labelled insulin for the binding sites after removal of the fetal calf serum from the culture medium.

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