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The surface germinal epithelium of the rat ovary was isolated and grown in vitro. Cytosol from cultured cells contained a saturable component, of sedimentation coefficient 7·5–8·5S, which bound oestrogenic and antioestrogenic substances with high affinity (K_d 400 pmol/l). Nuclei isolated from cells exposed to [³H]oestradiol contained radioactivity partially susceptible to KC1 extraction. Sedimentation analysis of the KC1 extract showed that [³H]oestradiol was associated with a moiety of sedimentation coefficient 4·5–5S.

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				K. F. Roby, C. C. Taylor, J. P. Sweetwood, Y. Cheng, J. L. Pace, O. Tawfik, D. L. Persons, P. G. Smith, and P. F. Terranova Development of a syngeneic mouse model for events related to ovarian cancer Carcinogenesis, April 1, 2000; 21(4): 585 - 591. [Abstract] [Full Text] [PDF]

				T. C. Hamilton Re: Hormonal Etiology of Epithelial Ovarian Cancer, With a Hypothesis Concerning the Role of Androgens and Progesterone J Natl Cancer Inst, April 7, 1999; 91(7): 650 - 650. [Full Text] [PDF]

				H. A. Risch RESPONSE - Re: Hormonal Etiology of Epithelial Ovarian Cancer, With a Hypothesis Concerning the Role of Androgens and Progesterone J Natl Cancer Inst, April 7, 1999; 91(7): 650a - 651a. [Full Text] [PDF]