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Homogenates of the submaxillary glands of immature and mature pigs were incubated with ³H-labelled C₁₉ steroids which have been shown previously to be metabolized in vitro by the submaxillary gland of mature boars. Dehydroepiandrosterone was metabolized largely to androstenedione, 5-androstane-3,17-dione and androsterone, and to small amounts of testosterone, 5-dihydrotestosterone and 5-androstanediols. Testosterone yielded predominantly 5-androstane-3,17β-diol with smaller amounts of other 5-reduced products, i.e. 5-dihydrotestosterone, 5-androstane-3β,17β-diol, 5-androstane-3,17-dione and androsterone; 5-dihydrotestosterone and the two epimeric 5-androstane-3/3β,17β-diols were interconverted. These and earlier results show that the porcine submaxillary gland has the capacity in vitro to metabolize selected C₁₉ steroids in a way which is not related to either sexual maturity or sex of the animal; in this respect the findings support certain aspects of previous histochemical studies.