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Human pituitary FSH increased the incorporation of [5-³H]uridine into RNA in vivo in the testes of intact 9-day-old mice and of hypophysectomized adults. In both groups the effect was greatest 8 h after administration of 5–7·5 i.u. FSH. Autoradiographs were prepared from the testes of hypophysectomized adult mice given subcutaneous injections of FSH or of 0·9% saline 6 h, and [5-³H]uridine 1·5 h, before death. Treatment with FSH caused statistically significant increases in the density of silver grains over the nuclei of Sertoli cells, type A and intermediate spermatogonia, and preleptotene and mid-pachytene primary spermatocytes. It was concluded that FSH has a generalized stimulatory action on RNA synthesis in the nuclei of Sertoli cells and those types of germinal cell which synthesize RNA most actively.

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				R. Kato, T. Maeda, T. Akaike, and I. Tamai Nucleoside Transport at the Blood-Testis Barrier Studied with Primary-Cultured Sertoli Cells J. Pharmacol. Exp. Ther., February 1, 2005; 312(2): 601 - 608. [Abstract] [Full Text] [PDF]