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The half-life for the disappearance of immunoreactive -melanotrophin in plasma following intravenous injection of synthetic hormone was measured before and after occlusion of the blood supply to certain organs in the anaesthetized rat. Occlusion of the blood supply to the liver, gut, spleen and pancreas, and of the renal circulation caused non-significant increases in half-life of 2·8 and 10·7% respectively. The importance of peripheral tissues in the clearance of -melanotrophin was demonstrated by the significant 63·4% increase in half-life caused by occlusion of the blood supply to sections of skeletal muscle, fat and skin.