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The disappearance rates of radioactive 3,5,3'-tri-iodothyronine (T₃) and 3,3',5'-tri-iodothyronine (reverse T₃) from plasma were investigated in young pigs receiving various levels of food intake. The rate of utilization of reverse T₃ decreased when intake was decreased to zero, whilst the rate of utilization of T₃ was unaffected.