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The effect of a single dose of 1 ml. 1:1000 adrenaline hydrochloride on the peripheral blood picture of fourteen normal human subjects was studied and an erythrocytosis and leucocytosis was seen in all the subjects. The magnitude of the variations observed have been recorded. No increase in the percentage of reticulocytes or a left shift in the granulocytes was noted.

As the size of the post-adrenaline erythrocytosis and leucocytosis did not diminish in four splenectomized subjects, it is suggested that splenic contraction is not the causal factor of these phenomena in man.

It seems that the post-adrenaline erythrocytosis in man is due to haemoconcentration, the granulocytosis to a mobilization of cells from the bone marrow and the lymphocytosis to a mobilization of cells from the lymph nodes and other lymphoid tissues in the body.

The variations in the salivary leucocytes after adrenaline show that, when the effect of the drug begins to wear off and the blood leucocyte level begins to fall, leucocytes are eliminated in the saliva.

When repeated injections of adrenaline were given to two normal subjects the magnitude of the lymphocytosis was no greater than after a single injection; on the other hand, a very large cumulative granulocytosis occurred, but no left shift was detected. It is suggested that the difference is probably due to the different rates of elimination and/or destruction of these cells in the body.