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Department of Physiology, Stanford University School of Medicine, Stanford, California 94305, U.S.A.

(Received 26 September 1977)

Pituitary-testicular function changes substantially with increasing age in male rats; the levels of testosterone and gonadotrophins in the circulation are reduced in old animals (Ghanadian, Lewis & Chisholm, 1976; Riegle & Meites, 1976; Chan, Leathem & Esashi, 1977). However, previous studies compared only young and very old rats (more than 18 months) and the development of age-related changes in the concentrations of testosterone and gonadotrophins has not been examined. Since ageing is a complex interaction of physiological changes over a prolonged period of time, information on the precise timing of the various changes is important in establishing functional relationships in the ageing process. This study investigates hormonal changes in a group of male rats between 8 and 21 months old.

Adult male Long–Evans rats were housed three/cage in a temperature-controlled room with a 14

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