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Division of Pharmacodynamics and Toxicology, College of Pharmacy, 644 Northeast 14th Street, Health Sciences Center, Oklahoma City, Oklahoma 73104, U.S.A.

(Received 30 September 1977)

The secretion of calcitonin in vitro has recently been examined in various mammalian and submammalian species. It appears that calcium and other calcitonin secretagogues produce a much greater secretory response in vivo than in vitro (Bell, 1970; Feinblatt, Raisz & Kenny, 1973; Gautvik & Tashjian, 1974; Selawry, Becker, Bivins, Snider & Silva, 1975). We have previously suggested that the relative unresponsiveness observed in vitro may be due to calcitonin-induced self-inhibition resulting from the accumulation of calcitonin in a closed incubation system in vitro (Orme & Pento, 1976), However, another possible explanation for the secretory unresponsiveness in vitro may be the occurrence of tissue-induced degradation of the secreted calcitonin. Therefore, the present study examined the influence of thyroid tissue from various species on the degradation of calcitonin