HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by RIGLER, G. L. Articles by RATNER, A. Search for Related Content PubMed PubMed Citation Articles by RIGLER, G. L. Articles by RATNER, A.

Departments of Physiology and Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, U.S.A.

(Received 19 August 1977)

Cyclic AMP has been increasingly implicated as an important intracellular mediator regulating the secretion of peptide hormones (Vale, Grant & Guillemin, 1973), but there is controversy concerning its role in the regulation of the luteinizing hormone releasing hormone (LH-RH)-stimulated secretion of luteinizing hormone (LH; Labrie, Pelletier, Borgeat, Drouin, Ferland & Belanger, 1976; Ratner, Wilson, Srivastava & Peake, 1976; Sundberg, Fawcett & McCann, 1976). Although less clearly established, the guanyl cyclase–cyclic GMP system may also play an important role in regulating cellular events (Goldberg, O'Dea & Haddox, 1973). Studies with a highly purified growth hormone (GH) releasing factor suggested the involvement of cyclic GMP in the mediation of GH release from the somatotrope (Wilson, Steiner, Dhariwal & Peake, 1974). This communication describes studies which suggest a role for the guanylate