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The neural lobe of the golden hamster contains one major and two minor proteins. The major protein was identified as a neurophysin in view of its electrophoretic properties, its high cysteine content and its depletion from the neural lobe upon saline imbibition.

The depletion of neurophysin and vasopressin from the neural lobe and the alterations of several indices of dehydration in the blood of the hamster were less than those found in the rat upon saline imbibition, suggesting that the hamster has a greater ability to adapt to conditions in which water is scarce.