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Cattedra di Semeiotica Medica 2 a and *Clinica Ostetrica e Ginecologica, University of Sassari, Viale San Pietro 12, 07100 Sassari, Italy

(Received 21 March 1977)

Recent evidence suggests that antioestrogens may interfere with secretion of prolactin. Tamoxifen inhibits oestrogen-induced release of prolactin in rats (Jordan, Koerner & Robison, 1975); furthermore, reduced levels of prolactin during fasting and blunted responses to synthetic thyrotrophin releasing hormone (TRH) have been reported in women with breast cancer undergoing treatment with tamoxifen (Willis, London & Butt, 1976). Another antioestrogen, clomiphene citrate, has been used with appreciable results to inhibit puerperal lactation (Zuckerman & Carmel, 1973; Weinstein, Ben-David & Polishuk, 1976), but it has no effect on the release of prolactin in normal man during fasting or hypoglycaemia, or after stimulation with synthetic TRH or sulpiride (Thomer, Besser, Hagen & McNeilly, 1974). We investigated the effect of clomiphene on the release of prolactin induced by mechanical