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Department of Obstetrics and Gynecology, Programme in Reproductive Biology, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada, L8S 4J9
(Received 23 April 1976)
In a previous communication it was observed that luteinizing hormone (LH) (10 µg/ml) had no effect on oestradiol production by rabbit follicles while testosterone production was greatly increased (YoungLai, 1974). In the same study lower concentrations of LH (1 and 10 ng/ml) appeared to stimulate oestrogen secretion. Whereas Mills, Davies & Savard (1971) showed that the rabbit follicle is extremely sensitive to LH, with good incorporation of [14C] acetate to oestrogens, Moor (1974) demonstrated that high levels of LH inhibit aromatization in sheep follicles. On the other hand, Ryle, Court, Smith & Morris (1975) found that immature mouse ovaries can produce oestrogen in the presence of LH and follicle-stimulating hormone (FSH), alone and in combination. Equine granulosa cells can aromatize testosterone to oestrogens in the presence of
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