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Laboratoire de Physiologie du Développement du Collège de France et de l'Université Pierre et Marie Curie, 4 place Jussieu, 75230 Paris Cedex 05, France

(Received 14 May 1976)

We have previously shown (Girard, Kervran, Soufflet & Assan, 1974; Kervran & Girard, 1974) that the rat foetus in utero responds to a 1 h glucose infusion into the mother by increasing its plasma insulin concentration. This response was present as early as day 18·5 of gestation (Kervran & Girard, 1974). These findings have been confirmed in 21-day-old rat foetuses (Blazquez, Lipshaw, Blazquez & Foa, 1975). In the present investigation we report the dynamics of plasma insulin changes in the rat foetus in utero after a glucose infusion to the mother.

Female rats of the Sherman strain were anaesthetized with sodium pentobarbitone (30 mg/kg body wt) on day 21·5 of gestation and infused with glucose via the saphenous vein by a two-step