HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by ECKSTEIN, B. Articles by YEHUD, S. Search for Related Content PubMed PubMed Citation Articles by ECKSTEIN, B. Articles by YEHUD, S.

The metabolism of progesterone in the 1000 g supernatant fraction of homogenates of ovaries from PMSG-treated immature rats was determined. As early as 52 h after a single injection of 50 i.u. PMSG, still before the LH surge, 5-pregnane-3,20-diol was identified as the main metabolite, together with smaller quantities of 3-hydroxy-5-pregnan-20-one and 5-androstane-3,17β-diol. Similar incubations of untreated rat ovaries at the same age did not produce 5-pregnane-3,20-diol. The quantities of 3-hydroxy-5-pregnan-20-one and 5-androstane-3,17β-diol were reduced in PMSG-treated rat ovaries as compared with control ovaries. When progesterone metabolism was examined 64 h after PMSG administration, 5–7 h after the peak of the LH surge but still before ovulation, 75% of the substrate was converted to 5-pregnane-3,20-diol, while 3-hydroxy-5-pregnan-20-one as well as 5-androstane-3,17β-diol could not be detected.