HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by ECKSTEIN, B. Articles by GOLDHABER, G. Search for Related Content PubMed PubMed Citation Articles by ECKSTEIN, B. Articles by GOLDHABER, G.

The effect of 5-androstane-3,17β-diol, its 3β epimer and oestradiol benzoate on suppression of LH release after ovariectomy was studied in immature rats. At doses of 50 and 100 µg/100 g body weight/day the 3 compound suppressed LH release after ovariectomy to the same extent as 0·1 µg oestradiol benzoate/100 g/day. 3-Androstanediol at a dose of 25 µg/100 g/day suppressed LH release only up to day 45 of life, while the same dose of the 3β epimer had no effect on LH suppression. The effect of 3β-androstanediol on inducing precocious vaginal opening was found to be mediated by the ovaries, since it was eliminated by ovariectomy. These results confirm our previous findings on the participation of androstanediol in the normal regulation of LH and in the mechanism of onset of puberty in the rat.