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I.N.R.A., Theix, 63110 Beaumont and *Laboratoire de Physiologie du Développement, Université Pierre et Marie Curie, 9 quai St Bernard, 75230 Paris Cedex 05, France

(Received 19 January 1976)

The existence of a gastrointestinal-thyroid 'C' cell axis has been proposed as an integral part of postprandial calcium homeostasis (Care, Bates, Swaminathan & Ganguli, 1971). Gastrin or pentagastrin administration to 3-month-old lambs (30 kg body weight) induces a decrease in plasma calcium concentration which does not occur in thyroidectomized animals (Barlet, 1972). Gastrin injection into 1-h-old fasted newborn lambs fails to decrease and increase respectively plasma calcium and calcitonin (CT) concentrations (Barlet, Michel, Thériez, Savajol & Garel, 1974). Thus gastrin seems effective in stimulating CT secretion after weaning but not before. However, calcium chloride (10 mg Ca/kg body weight) given orally to these newborn lambs triggers an increase of CT secretion 1 h later whereas plasma calcium concentrations remain unchanged (Barlet et al.