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Queen Elizabeth Hospital, Birmingham, B15 2TH, and *Department of Clinical Endocrinology, Women's Hospital, Birmingham, BU 4HL

(Received 19 January 1976)

Administration of the natural or synthetic decapeptide known as luteinizing hormone/follicle-stimulating hormone releasing hormone (LH-RH) causes prompt release of both luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The decapeptide has a short half-life of only a few minutes, so that its use as a therapeutic agent in the treatment of infertility is limited. Attempts have been made therefore to synthesize more potent and longer-acting analogues. Many of these have only weak activity in experimental animals, but some, notably those with modifications to structure at residues 5, 6 and 10, are more effective (Arimura, Vilchez-Martinez, Coy, Coy, Hirotsu & Schally, 1974; Kastin, Arimura, Gonzalez-Barcena, Coy, Clinton-Miller, Nishi, Lee, Duron-Huerta, Schalch & Schally, 1974a; Kastin, Schally, Gonzalez-Barcena, Coy, Clinton-Miller, Porias & Schalch, 1974b; Vilchez-Martinez, Coy, Arimura, Coy, Hirotsu & Schally, 1974; Zañartu,