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Department of Physiology, Medical School, Newcastle upon Tyne, NE1 7RU

(Received 19 December 1975)

It has been suggested that female sex hormones confer some protection against peptic ulceration though how this is effected is not known (Crean, 1963). We have observed the effects of these hormones on gastric secretions and serum gastrin concentration.

Experiments were carried out on 14 conscious cats with gastric fistulae. The cats were starved for 36 h before the experiments. Access to water was allowed. Blood sampling, collection of gastric juice and measurements of acid output (Albinus, Blair, Grund, Reed, Sanders, Gomez-Pan, Schally & Besser, 1975), pepsin secretion (Chiang, Sanchez-Chiang, Wolf & Teng, 1966) and protein content (Lowry, Rosebrough, Farr & Randall, 1951) have been described elsewhere. Serum gastrin was measured by radioimmunoassay (Blair, Grund, Lund, Reed, Sanders, Shale, Shaw & Wilkinson, 1976) which had a sensitivity of 9 pg/ml serum. The results are expressed as