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A.R.C. Institute of Animal Physiology, Babraham, Cambridge, CB2 4AT

(Received 16 July 1975)

The maintenance of lactation in the rabbit depends markedly on prolactin secretion (Cowie, Hartmann & Turvey, 1969). Other studies in this species have shown that after about 18 days of lactation, while milk yield remains relatively high, there are marked changes in milk composition; the administration of prolactin reverses or prevents this change in composition (see Linzell & Peaker, 1971). Therefore it is clearly desirable to reduce prolactin secretion earlier in lactation to investigate the effects on milk composition and yield.

Since bromocriptine (2-bromo--ergocryptine-methane-sulphonate; CB154, Sandoz) is widely used to suppress prolactin secretion we have attempted to study its effects on milk secretion in rabbits at a relatively early stage of lactation. Rabbits of a Dutch strain suckling 4–7 young were used; the methods employed, and their validity for determining milk yield and composition have been described