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MRC Environmental Physiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT and * Army Personnel Research Establishment, R.A.E. Farnborough, Hampshire

(Received 22 February 1975)

It has been shown that passive heating first leads to a decrease in the level of plasma cortisol, but when body temperature exceeds about 38·3 °C increased cortisol secretion reverses this trend, and the level of plasma cortisol rises (Collins, Few, Forward & Giec, 1969). Also Okada, Matsuoka & Kumahara (1972) have shown that mild hyperthermia leads to a rise in the level of plasma growth hormone (GH). However, the relationship between GH secretion and cortisol secretion in more severe hyperthermia has not been studied. We have studied changes in plasma GH and cortisol in eight men whose body temperature was raised rapidly by mild exercise in a hot environment.

Eight healthy male subjects aged between 18 and 29 years were