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Department of Obstetrics & Gynecology, The Memorial Hospital, Worcester, Massachusetts, and *Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545, U.S.A.

(Received 14 January 1975)

Evans & Hähnel (1971) and Trams, Engel, Lehmann & Maass (1973) have reported that during the endometrial proliferative stage of the human menstrual cycle oestrogen-binding capacity is high, but during the secretory stage of the cycle, when progesterone is the dominant ovarian hormone, oestrogen-binding capacity is reduced. Sucrose density gradient analysis of human uterine cytosol has demonstrated oestradiol-17β-binding components sedimenting at 5 S (Wyss, Heinrichs & Herrmann, 1968) or 4 S and 8 S (Martin, 1972) although in neither study was the cycle time of the tissue reported.

Evans & Hähnel (1971) found that bound oestradiol-17β was located in the endometrium and the present study was undertaken to determine the presence or absence of the 8 S oestrogen-binding component in human endometrium during the menstrual cycle.