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Departamento de Ciencias Químicas y Fisiológicas, Sede Santiago Sur, Universidad de Chile, Casilla 3931, Santiago, Chile

CONTENTS: PAGE

Introduction 287

Pre-transcriptional aspects of the mechanism of action of androgens 288

Binding of androgens to plasma proteins 288

The metabolism of androgens in the androgen-sensitive tissues 290

The binding of androgens to cytoplasmic receptors 291

Prostate 292

Kidney 293

Muscle 293

Bone marrow 294

Skin 294

Urogenital tract of the embryo 294

The binding of androgens to other cytoplasmic components 295

The nuclear binding of androgens 296

Nuclear receptor sites 296

Nuclear acceptor sites 298

Transcriptional and post-transcriptional aspects of the mechanism of action of androgens 299

Action on chromatin template capacity and activity 299

Action on RNA polymerase 301

Action on biosynthesis and pool size of RNA precursors 302

Action on RNA maturation 302

Action of androgens on protein biosynthesis 303

Action of androgens on DNA synthesis 304

Some comments on the effect of androgens on transcriptional and post-transcriptional events 304

General remarks 305

References