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Department of Obstetrics & Gynecology, Gunma University School of Medicine, Maebashi, Japan

(Received 3 September 1974)

Several investigators (Tsafriri, Koch & Lindner, 1973; Sato, Taya, Jyujo & Igarashi, 1974) have reported that a single injection of indomethacin, an inhibitor of prostaglandin (PGs) synthesis, does not block luteinizing hormone (LH) release but exerts its anti-ovulatory action directly on the ovary. However, it has been shown (Harms, Ojeda & McCann, 1973) that PGs have stimulatory effects at various levels of the hypothalamic-pituitary system.

Adult female rats of the Holtzman strain were used 5 weeks after ovariectomy. Serum or plasma, and pituitary levels of LH were determined using a radioimmuno-assay kit (NIAMD-NIH). In Expt 1, 3 mg indomethacin (Sumitomo Kagaku Pharmaceutical Co., Osaka) were injected s.c. in 0·2 ml 15% gelatin, with or without PGF₂ (Ono Pharmaceutical Co., Osaka) (0·8 mg/rat) daily for 5 days and blood samples were collected 24 h