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Department of Diagnostic Endocrinology, University Children's Hospital, Tübingen, and *Chemisches Institut, University of Tübingen, Germany

(Received 11 July 1974)

The action of a synthetic tetrapeptide (PyroGlu-Tyr-Arg-TrpNH2), synthesized by the solid-phase method, on the release of luteinizing hormone (LH) in vivo, has been established (Bowers, Chang, Sievertsson, Bogentoft, Currie & Folkers, 1971; Sievertsson, Chang, Bogentoft, Currie, Folkers & Bowers, 1971). These investigators, however, observed that this peptide was not able to release follicle-stimulating hormone (FSH). The present study was undertaken to synthesize the tetrapeptide by a method other than the usual solid-phase technique (Voelter & Zech, 1972; Zech, 1973), to see whether this synthetic tetrapeptide can induce the release of both gonadotrophins and androgens in rats and whether this release is age-dependent.

Because of the observed disadvantages, such as the formation of 'failure sequences' and 'truncated sequences' (Bayer, 1969; Voelter, Zech & Grubhofer, 1973), which are difficult to eliminate during synthesis,