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Lactation was induced in non-pregnant, intact ewes. The injection of 60 mg progesterone plus 240 µg oestradiol benzoate every third day for 60 days increased udder size. Subsequent daily injection of 10 mg dexamethasone trimethylacetate or 5 mg oestradiol benzoate plus 12·5 mg progesterone for 6 days led to further udder development and initiated secretion of fluid similar in appearance and composition to normal ovine milk.

Both treatments were equally effective in initiating milk secretion and subsequent production (approximately 0·50 kg/day) was similar to that of ewes lactating after normal pregnancy [0·59 ± 0·06 (S.E.M.) kg/day]. Glands of ewes receiving no treatment other than milking after oestrogen and progesterone priming remained small in size and produced only trivial volumes of secretion when milked out daily for 14 days.