HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by FINN, C. A. Search for Related Content PubMed PubMed Citation Articles by FINN, C. A.

The antibiotic actinomycin D blocks pregnancy in mice when administered as a single dose (15 µg) on the fourth day after mating (Finn & Martin, 1972). Experiments using ovariectomized pregnant mice, induced to implant with exogenous ovarian hormones and maintained on progesterone, showed that after the administration of the drug the early stages of implantation [the attachment of the trophoblast to the uterine epithelium (Pollard, Bredl & Finn, 1973), stromal oedema and increased vascular permeability (Finn & Bredl, 1973)] proceed normally but transformation of the stromal cells into decidual cells and degeneration of the uterine epithelium are delayed for about 30 h. A further finding was that the blastocysts, in spite of the drug, were stimulated to continue their development at the normal time. This was interesting because it suggested that whatever the nature of the stimulus given to the blastocyst at the time of implantation it was not dependent on