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In the preceding paper a description has been given of the mitosis-stimulating effects of starch and of oestrone. Preliminary arguments have been advanced which suggest that the modes of action are not identical, although, by a mobilization of sugar and glycogen, oestrone may be assisted in its action by the starch effect. In the present paper an attempt is made to distinguish further between the mitosis-stimulating actions of these two substances.

In the course of the investigation it became obvious that the epidermal mitosis rate of the female mouse differs markedly from that of the male, and an analysis of this related point is also included.

MATERIAL AND METHODS: The animals used were all adults of the Kreyberg's white label and Strong's CBA strains, and no obvious differences were found between them. The details of the methods of feeding, heating and lighting are given in a paper by Bullough [1946]