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Tracer methods with radioactive iodine have been employed in recent years to assess human thyroid function. Some authors measured the uptake of I¹³¹ by the thyroid, [Hamilton & Soley, 1940; Hertz, Roberts & Salter, 1942; Rawson, Evans, Means, Peacock, Lerman & Cortell, 1944; and others]: other authors measured the excretion [Hamilton & Soley, 1939; Keating, Power, Berkson & Haines, 1947; Skanse, 1948; and others]. Extensive investigations have been carried out with the help of radioactive iodine on the iodine metabolism in the thyroid function of animals (recently reviewed by Rawson & McArthur [1947]; Chaikoff & Taurog [1948] and Hevesy [1948]). The results of these experiments have so far been utilized only in a very restricted way for diagnostic purposes on human patients.

Although various tracer doses, with and without carrier, have been used, up to the present no standardized routine method for the investigation of patients has been developed.