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Prostaglandin F₂ (PGF₂) has been shown to possess luteolytic properties in several species including the rabbit (Duncan & Pharriss, 1970; O'Grady, Kohorn, Glass, Caldwell, Brock & Speroff, 1972). Surgical removal of the corpus luteum leads to parturition in the rabbit. Thus, PGF₂ should initiate parturition in this species. In primates, controversy has arisen over the ability of PGF₂ to produce luteolysis (Kirton, Pharriss & Forbes, 1970). Since prostaglandins are very rapidly cleared by the pulmonary circulation, observed discrepancies may be due to the actual route of administration and dosage used.

Experiments have been carried out to measure the effect of PGF₂ in producing parturition in the pregnant rabbit. PGF₂ was infused continuously into rabbits with an indwelling aortic catheter (Nathanielsz & Abel, 1972). Infusions were started on day 21 and continued until delivery. PGF₂ was infused at dose rates varying from 1·125 ng/h