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Ovulation-inducing effects of pregnant mare serum gonadotrophin (PMSG) were studied in immature female rats treated on day 5 (day 1 = day of birth) with oil or with 5 or 1250 µg testosterone propionate (TP). The response of rats treated with 1250 µg TP was negligible regardless of the age of the animals and of the dose of PMSG. The response of rats treated with 5 µg TP to PMSG alone was low (36% of rats, with 2·6 ova/ovulating rat), but could be improved by progesterone administration 2 days after PMSG injection (91% of rats, with 14·5 ova/ovulating rat). At every age and dose of PMSG tested the response of animals treated with 5 µg TP to combined PMSG and progesterone treatment was less than that of control animals.

It is concluded that neonatal TP treatment diminishes the release of endogenous ovulating hormone subsequent to PMSG injection. This effect is dependent on the dose of TP used, but already demonstrable in animals treated with 5 µg TP on day 5, which would have been cyclic and fertile after puberty.

Only for the animals treated with 1250 µg TP could a decreased sensitivity of the ovaries to combined administration of PMSG and human chorionic gonadotrophin be demonstrated.