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The microsomal fraction of testicular tissue from Japanese quail (Coturnix coturnix japonica) was incubated with 4-¹⁴C-labelled pregnenolone, progesterone, 17-hydroxyprogesterone, androstenedione, dehydroepiandrosterone and testosterone and [7-³H]17-hydroxypregnenolone in a medium containing either NAD or NADPH. The metabolic products were identified by their mobilities on thin-layer chromatograms, derivative formation after oxidation and acetylation of the metabolites, and recrystallization to constant specific activity.

Three pathways for testosterone formation by the testes are suggested by the results: the first via progesterone, 17-hydroxyprogesterone and androstenedione; the second via 17-hydroxypregnenolone, dehydroepiandrosterone and androstenedione; and the third via 17-hydroxypregnenolone, dehydroepiandrosterone and androst-5-ene-3β,17β-diol.