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Two pituitary hormones, luteinizing hormone (LH) and prolactin, influence the steroid synthetic capacity of ovarian tissue in several species (Greep, 1971). Prolactin increases cholesterol content of rabbit interstitial tissue (Hilliard, Spies, Lucas & Sawyer, 1968), while LH increases the synthesis of progestational steroids from cholesterol (Dorrington & Kilpatrick, 1966; Solod, Armstrong & Greep, 1966). Adenosine 3',5'-monophosphate (cyclic AMP) has been implicated as an intermediate in the action of LH in the ovary (Hall & Koritz, 1965; Marsh, Butcher, Savard & Sutherland, 1966; Dorrington & Kilpatrick, 1967) and theophylline, an inhibitor of cyclic nucleotide phosphodiesterase, increases the effect of LH on steroidogenesis in vitro. Much of the evidence implicating cyclic AMP as a mediator of hormone action has been obtained from experiments in vitro and very large amounts of cyclic AMP or derivatives are necessary to alter metabolic activity in vivo (Levine, 1970). In order to investigate the possibility of regulating