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In-vitro incorporation of l-[³H]phenylalanine into proteins of the anterior, middle and posterior hypothalamus was measured in female rats given androgen soon after birth and in castrated rats. The results were compared with control animals during the sexual cycle.

Protein synthesis in the anterior hypothalamic area was higher during pro-oestrus than during oestrus and dioestrus, and lower in dioestrous than in oestrous rats. Castrated rats showed a similar rate of incorporation in this area as in the oestrous group. Protein synthetic activity in the anterior hypothalamus of androgenized rats was as low as in normal rats during dioestrus.

The highest radioactivity in the proteins of the posterior hypothalamus was found in oestrous rats. The androgenized group showed a rate of incorporation significantly higher than in dioestrus and pro-oestrus, but lower than during oestrus. Castration significantly increased the rate of incorporation of labelled amino acid into protein of the posterior hypothalamic area, as compared with the specific activity found in dioestrous and pro-oestrous groups.