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Even though several attempts have been made to attribute a physiological role to calcitonin (CT) during calcium stress (Gray & Munson, 1969), the role of CT in calcium homeostasis during normocalcaemia has not yet been defined.

The role of normocalcaemic secretion of CT in calcium homeostasis was investigated in young pigs of either sex weighing 20–26 kg. Pigs were anaesthetized with phencyclidine and pentobarbitone, after an overnight fast. A femoral artery and a vein were catheterized and the thyroid gland was isolated (Care, Cooper, Duncan & Orimo, 1968). After taking five to six control blood samples for calcium estimation, the thyroid gland was removed and the plasma calcium concentration measured every 10 min and corrected for variation in plasma total solids (Care, Duncan & Webster, 1967).

In all seven experiments, thyroidectomy produced a significant elevation of plasma calcium concentration over a period of 47–118 min after thyroidectomy (Fig. 1).

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