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The anterior pituitary has an important role in the control of sebaceous gland activity. This effect is mediated in part by thyrotrophic hormone (TSH) and adrenocorticotrophic hormone (ACTH) through their actions on the thyroid and adrenal glands respectively (Thody & Shuster, 1970a, 1971, 1972a). Ablation and replacement experiments suggest that the gonads also have a major influence (Thody & Shuster, 1970a, b), but although there is evidence that gonadotrophins will stimulate sebaceous glands in the human male (Strauss & Pochi, 1963) no data are available from experimental animals. We therefore decided to examine the effect of gonadotrophins on sebum secretion in the rat.

Male Wistar rats were hypophysectomized when 8–9 weeks old and 4 weeks later received either 0·9 units human menopausal gonadotrophin (Humegon)/day or no treatment. Humegon was dissolved in 0·9% NaCl solution and subcutaneous injections were given daily for a period of 2 weeks. At