HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by DIKSTEIN, S. Articles by SULMAN, F. G. Search for Related Content PubMed PubMed Citation Articles by DIKSTEIN, S. Articles by SULMAN, F. G.

In a previous paper an attempt was made to minimize the effect of random variations during routine toxicological screening in female rats, by using all the previously accumulated control experiments for comparison (Dikstein, Kaplanski, Koch, Locker & Sulman, 1967). The method is based on comparison of organ weights of the treated animals with computer-drawn curves showing the standard weight of organs as a function of body weight in control animals. This method allows the use of as few as six rats for each treatment and six control rats. The method obviates misinterpretation of body weight changes caused either by the treatment or by uncontrollable changes in experimental conditions. In this communication we describe a method developed for use in male rats.

The basic approach is as follows. Using all the data accumulated in previous control experiments, a regression line between a certain measurable parameter (usually the weight of a specific

This article has been cited by other articles:

				S. A. Bailey, R. H. Zidell, and R. W. Perry Relationships Between Organ Weight and Body/Brain Weight in the Rat: What Is the Best Analytical Endpoint? Toxicol Pathol, June 1, 2004; 32(4): 448 - 466. [Abstract] [PDF]