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Normal and dexamethasone-treated guinea-pigs were injected intravenously with 50 ng ¹³¹I-labelled ^1–24 adrenocorticotrophin (ACTH). The concentration of radioactivity in the adrenals of dexamethasone-treated animals was significantly greater than in the untreated group but no difference was observed among the other tissues studied. There was no change in the concentration of ¹²⁵I-labelled insulin, ¹²⁵I-labelled poly-L-tyrosine, ¹³¹I-labelled bovine serum albumin (BSA) or [¹³¹I]iodide in any tissue including the adrenal. Intra-adrenal radioactivity after the injection of ¹³¹I-labelled ^1–24 ACTH into normal animals showed a peak approximately localized at the glomerular-fascicular border with a second peak in the zona reticularis. Dexamethasone treatment significantly enhanced the size of both peaks. There was no difference in the intra-adrenal distribution of ¹²⁵I-labelled BSA, ¹²⁵I-labelled insulin and ¹²⁵I-labelled poly-L-tyrosine after dexamethasone administration. The effect of other proteins on the increased uptake of ¹³¹I-labelled ^1–24 ACTH by the adrenal of dexamethasone-treated animals was also studied. Human luteinizing hormone (100 ng), human growth hormone (100 ng), poly-L-tyrosine (50 ng) and glucagon (10, 100 and 1000 ng) were without effect. Excess ^1–24 ACTH (100 µg) and insulin (100 and 1000 ng) reduced adrenal radioactivity to the concentrations found in control animals.