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Many female thyrotoxics have a decreased menstrual flow, to an extent apparently related to the severity of the disease (Russell & Dean, 1942). In spite of this, and other observations on the enlargement of the thyroid in relation to the functional changes (certainly affecting the ovary) of puberty, pregnancy and the menopause, very little is known of the interaction between the thyroid gland and the hypothalamo—pituitary—gonadal system. Plasma (or urinary) levels of luteinizing hormone (LH) in these patients have not yet been reported.

Six female patients with thyrotoxicosis who were seen at the out-patient clinic were studied. Four of these patients had hypomenorrhoea, i.e. scanty regular menstrual periods, and the other two had secondary amenorrhoea. Blood samples were collected daily at a constant time of day from each patient for 28 days before starting therapy. Plasma was separated within 1 h and kept frozen at –23 °C until assayed.