HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by McCONAGHEY, P. Articles by DEHNEL, J. Search for Related Content PubMed PubMed Citation Articles by McCONAGHEY, P. Articles by DEHNEL, J.

It has been shown that labelled human growth hormone, when injected into intact or hypophysectomized rats, accumulates in the liver and kidney (De Kretser, Catt, Burger & Smith, 1969; Mayberry, Van den Brande, Van Wyk & Waddell, 1971). McConaghey & Sledge (1970) showed that rat liver, when perfused with bovine growth hormone (BGH) in a chemically defined medium, was capable of producing ' sulphation factor'. 'Sulphation factor' (SF) is thought to be a secondary growth factor since it stimulates the proliferation of epiphysial chondrocytes and synthesis of cartilage matrix (Daughaday & Kipnis, 1966). The present communication describes similar findings when rat kidney is treated with BGH, either by perfusion in situ or by the incubation of slices in vitro.

The medium used for controls, perfusions and the incubation of slices was Waymouth's MB 752/1 with 0·5% bovine serum albumin, 100 units penicillin/ml and 100 mg streptomycin/ml added. The kidneys of normal