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J. PRESL, J. POSPÍIL, V. FIGAROVÁ

Rats do not respond to human chorionic gonadotrophin (HCG) in the first days of life: oestrogen is apparently not secreted after treatment with HCG until the animals are 8–9 days old (Freed & Soskin, 1937; Falck, 1953). Similar results have been obtained in our colony of Wistar rats (Divila, Presl, Krabec & Horsk, 1971). An attempt was made to study the relationship of the age-dependent stage of rat ovarian development and the refractory condition of the ovary with the beginning of its responsiveness to HCG, by means of an autoradiographic technique after injection of ¹²⁵I-labelled HCG.

Human chorionic gonadotrophin (Organon, Oss; biological activity of 8000 i.u./mg) was iodinated by the method of Greenwood, Hunter & Glover (1963) using ¹²⁵I (The Radiochemical Centre, Amersham). The average specific activity was 35 µCi/µg protein. Groups, each of five Wistar rats aged 5–30 days, were injected i.p. with a single dose of

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